Unilateral prostate enlargement
The derived LOAEC for systemic effects was 32 ppm taking into account the decrease in sperm motility for male mouse exposed to vapour concentrations of 32 ppm and higher concentration levels.
All animals survived to the end of the study. The absolute weights of the liver, right kidney, and thymus of ppm males; heart, liver, and right kidney of ppm females; and thymus of 62 and ppm females were significantly less than those of the chamber controls.
The relative weights of the heart, right kidney, lung, and right testis of ppm males and the lung of ppm females were significantly greater than those of the chamber controls.
Except for a slight 0.
Histopathologic changes were noted primarily in the nasal cavity and involved both the respiratory and olfactory epithelium of males and females principally in the 62 or ppm groups. These lesions included suppurative inflammation, squamous metaplasia of the respiratory unilateral prostate enlargement, olfactory epithelial atrophy, and necrosis of the turbinates. Significant olfactory epithelial atrophy was already observed after treatment with 32 ppm.
A NOAEC of 16 ppm for local effects was derived based on the observed nonneoplastic lesions of the mouse nose. The derived LOAEC for systemic effects was 32 ppm taking into account the decrease in the sperm motility for male mouse exposed to vapour concentrations of 32 ppm and higher concentration levels.